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Tegretol, carbamazepine USP, is an anticonvulsant and specific analgesic
for trigeminal neuralgia, available for oral administration
  as chewable tablets of 100 mg, tablets of 200 mg, XR tablets of 100, 200, and 400 mg, and
as a suspension of 100 mg/5 mL teaspoon
 
INDICATIONS

Epilepsy

Tegretol is indicated for use as an anticonvulsant drug. Evidence supporting efficacy of
Tegretol as an anticonvulsant was derived from active drug-controlled studies that
enrolled patients with the following seizure types:

    * Partial seizures with complex symptomatology (psychomotor, temporal lobe). Patients
with these seizures appear to show greater improvement than those with other types.
    * Generalized tonic-clonic seizures (grand mal).
    * Mixed seizure patterns which include the above, or other partial or generalized
seizures. Absence seizures (petit mal) do not appear to be controlled by Tegretol

Trigeminal Neuralgia

Tegretol is indicated in the treatment of the pain associated with true trigeminal neuralgia.


Beneficial results have also been reported in glossopharyngeal neuralgia.

This drug is not a simple analgesic and should not be used for the relief of trivial aches or pains
 
DOSAGE AND ADMINISTRATION

Tegretol suspension in combination with liquid chlorpromazine or thioridazine
results in precipitate formation, and, in the case of chlorpromazine, there has been
a report of a patient passing an orange rubbery precipitate in the stool following
coadministration of the two drugs . Because the extent to which this occurs with
other liquid medications is not known, Tegretol suspension should not be administered
simultaneously with other liquid medications or diluents.

Monitoring of blood levels has increased the efficacy and safety of anticonvulsants . Dosage
should be adjusted to the needs of the individual patient. A low initial daily dosage with
a gradual increase is advised. As soon as adequate control is achieved, the dosage may
be reduced very gradually to the minimum effective level. Medication should be taken with meals.

Since a given dose of Tegretol suspension will produce higher peak levels than the same
dose given as the tablet, it is recommended to start with low
doses (children 6-12 years: 1/2 teaspoon q.i.d.) and to increase slowly to avoid unwanted side effects.

Conversion of patients from oral Tegretol tablets to Tegretol suspension: Patients
should be converted by administering the same number of mg per day in
smaller, more frequent doses (i.e., b.i.d. tablets to t.i.d. suspension).

Tegretol-XR is an extended-release formulation for twice-a-day administration. When
converting patients from Tegretol conventional tablets to Tegretol-XR, the same
total daily mg dose of Tegretol-XR should be administered. Tegretol-XR tablets
must be swallowed whole and never crushed
or chewed. Tegretol-XR tabletstegretol,drug,seizure,health,epilepsy,human,nice should be
inspected for chips or cracks. Damaged tablets, or
tablets without a release portal, should not be
consumed. Tegretol-XR tablet coating is not absorbed
and is excreted in the feces; these coatings may be noticeable in the stool
 
Epilepsy

Adults and children over 12 years
of age - Initial: Either 200 mg b.i.d. for
tablets and XR tablets, or 1 teaspoon q.i.d. for
suspension (400 mg/day). Increase at weekly
intervals by adding up to 200 mg/day using a b.i.d. regimen
of Tegretol-XR or a t.i.d. or q.i.d. regimen of the other
formulations until the optimal response is obtained. Dosage generally should not
exceed 1000 mg daily in children 12-15 years of age, and 1200 mg daily in
patients above 15 years of age. Doses up to 1600 mg daily have been used in
adults in rare instances. Maintenance: Adjust dosage to the minimum
effective level, usually 800-1200 mg daily.

Children 6-12 years of age - Initial: Either 100 mg b.i.d. for tablets or XR
tablets, or 1/2 teaspoon q.i.d. for suspension (200 mg/day). Increase at
weekly intervals by adding up to 100 mg/day using a b.i.d. regimen of
Tegretol-XR or a t.i.d. or q.i.d. regimen of the other formulations until the
optimal response is obtained. Dosage generally should not exceed 1000 mg
daily. Maintenance: Adjust dosage to the minimum effective level, usually 400-800 mg daily.

Children under 6 years of age - Initial: 10-20 mg/kg/day b.i.d. or t.i.d. as
tablets, or q.i.d. as suspension. Increase weekly to achieve optimal clinical
response administered t.i.d. or q.i.d. Maintenance: Ordinarily, optimal clinical
response is achieved at daily doses below 35 mg/kg. If satisfactory clinical response
has not been achieved, plasma levels should be measured to determine whether or
not they are in the therapeutic range. No recommendation regarding the safety of
carbamazepine for use at doses above 35 mg/kg/24 hours can be made.

Combination Therapy: Tegretol may be used alone or with other anticonvulsants. When
added to existing anticonvulsant therapy, the drug should be added gradually while
the other anticonvulsants are maintained or gradually decreased, except
phenytoin, which may have to be increased

Trigeminal Neuralgia

Initial: On the first day, either 100 mg b.i.d. for tablets or XR tablets, or 1/2 teaspoon
q.i.d. for suspension, for a total daily dose of 200 mg. This daily dose may be
increased by up to 200 mg/day using increments of 100 mg every 12 hours for
tablets or XR tablets, or 50 mg (1/2 teaspoon) q.i.d. for suspension, only as
needed to achieve freedom from pain. Do not exceed 1200 mg daily. Maintenance:  Control
of pain can be maintained in most patients with 400-800 mg daily. However, some
patients may be maintained on as little as 200 mg daily, while others
may require as much as 1200 mg daily. At least once every 3 months
throughout the treatment period, attempts should be made to reduce the
dose to the minimum effective level or even to discontinue the drug
 
 
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